Solid Dosage Training Inc 497 Phoenix Circle, Vallejo, CA 94589
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Solid Dosage Training Inc

Solid Dosage Training and Troubleshooting, Inc. Courses for 2022*

I. Multiple Subject Courses

Basic Solid Dosage Manufacturing (with optional Encapsulation) NEW AND REVISED

The original two-day course is based on a concept conceived by Fred Rowley. It is now internationally recognized as the introductory course of choice. The course provides the basic knowledge needed to understand formulas, unit operations, manufacturing practices, common equipment used, and a thorough explanation of what it takes to make a quality tablet (or capsule). The course emphasizes solid dosage and capsule manufacturing theory and practice and discusses common tablet (& capsule defects) and problem-solving. There is no hands-on session/no workshop. Optional addition of a Hard Shell Capsule manufacturing module, 702 pages, 265 references

Basic Solid Dosage Manufacturing for the Active Pharmaceutical Ingredient (API) Manufacturer is a single-day course for the API manufacturer that provides the basic knowledge needed to understand the impact of active ingredient characteristics on tablet manufacturing. The course discusses the formulas, unit operations, manufacturing practices, and common equipment used and thoroughly explains what it takes to make a quality tablet. The course emphasizes the theory and practice of tablet manufacturing and discusses common tablet defects directly linked to the API used in the formula. 243 references, 470 pages

Successful Scale-Up of Solid Dosage Unit Operations

A two-day course that discusses the critical operating parameters and critical factors for successful scale-up of the granulating (high shear wet, dry, FBG), dry powder blending, tablet compressing, and aqueous film coating of the solid dosage forms. Seven hundred sixty pages, more than 1,000 references. Now available. 100+ pages, 100+ references.

Solid Dosage Manufacturing For Support Personnel

A single day course for support personnel (Contract manufacturing administrators, Regulatory Affairs, Quality Unit personnel, Chemists, Clerks, Technicians, Purchasing agents, etc.) that provides the basic knowledge needed to understand formulas, unit operations, manufacturing practices; common equipment used, and provides a thorough explanation of what it takes to make a quality tablet or capsule. The course emphasizes the theory and practice of tablet and capsule manufacturing and discusses common tablet & capsule defects and problem-solving. 243 references, 682 pages

II. Single Subject Courses

The Weighing Suite

This course has 3 hours in the classroom and is engineered to provide a comprehensive understanding of the weigh room suite, proper staging of materials and verification, the operator role, the weigher and checker, using established "best practice" procedures, the proper use of scales & balances and the staging and movement of materials to minimize mistakes. The course is a four-hour lecture on the theory and practice of successful weighing followed by an immediate workshop or hands-on demonstration in the weighing area. The textbook has a workshop. 25 references, 193 pages

Basic Powder Milling

This half-day course is engineered to provide a comprehensive view of the powder milling operation within a pharmaceutical or nutritional supplement manufacturing facility. The course is a four-hour lecture on the theory and practice of successful powder milling followed by an immediate hands-on demonstration in the granulating suite. Both the course and book contain a workshop with multiple problems. 192 pages, 176 references

Introduction to Powder Granulation NEW AND REVISED

This single-day course is engineered to provide a comprehensive view of the granulation operation within a pharmaceutical or nutritional supplement manufacturing facility. The single-day course is a six-hour lecture on the theory and practice of forming and drying a granule, the different equipment available for wet massing, and a discussion of critical processing parameters for each. This is followed by an immediate workshop or hands-on demonstration in the granulating area. Both the book and course contain a workshop with multiple problems to solve: two hundred ninety-eight references and 314 pages.

Advanced Powder Granulation

The course is the only advanced course of its kind given today. Students are presumed to have some knowledge of basic powder granulating processes and are prepared for a higher and more detailed course in powder granulating. This two-day course covers advanced topics such as the effect of low, medium, and high shear granulating, powders in general and how they behave, methods of granule assessment, and their direct impact on tablet defects. The course includes video examples of granulating processes, a workshop, and a problem-solving session. Three hundred eighty-six references, 362 pages.

Introduction to Fluidized Bed Granulation NEW AND REVISED

This single-day course is engineered to provide a comprehensive view of the fluidized bed granulation operation within a pharmaceutical or nutritional supplement manufacturing facility. The course has a four-hour lecture on the theory and practice of forming and drying a granule, emphasizing basic fluidized bed technology. An immediate hands-on demonstration follows this in the granulating suite. Both the course and book contain a workshop with multiple problems to solve. Two hundred sixty-four pages, 138 references.

Introduction to Roller Compaction NEW AND REVISED

A single-day course for operators and line staff on the dry granulating (roller compacting) and tablet slugging technologies. The four-hour classroom lecture discusses the science behind roller compacting, and the various available machines (Fitzpatrick/Gerteis/Alexanderwerk/Vector/Yenchen, etc.) is followed immediately by a two to four-hour hands-on demonstration in the wet granulating suite. There is a workshop with multiple problems to solve. One hundred forty-two references, 229 pages.

Introduction to High Shear Granulation NEW AND REVISED

A single-day course for operators and line staff on the high energy granulation technology (aka RMG, HEMG, HSGC, etc.). The course has a four-hour lecture on the theory and practice of forming and drying a granule, emphasizing basic high-energy granulating technology and the various available machines. An immediate hands-on demonstration follows this in the granulating suite. There is a workshop with multiple problems to solve. Two hundred twelve references, 209 pages.

Introduction to Dry Powder Blending

A single-day course that presents the theory and practice of dry powder blending, powder characteristics, blender class types, working principles, the advantages and disadvantages of each mixer type, and factors that influence the outcome. The four to the six-hour lecture is followed immediately by a workshop or a hands-on equipment demonstration. Both book and course contain a workshop with multiple problems to solve. 163 references, 163 pages

Advanced Dry Powder Blending

The course is the only advanced course of its kind given today. Students are presumed to have some knowledge of the basic dry powder blending process and are prepared for a higher and more detailed course in powder blending. This two-day course covers advanced topics such as the effect of low, medium, and high shear blending, blend time effects, and powders' movement. The course includes video examples of blending processes. The course has a workshop and a problem-solving session. Two hundred twenty-six references, 241 pages.

Optimized Dry Powder Blending And Sampling

A single-day course that presents the theory and practice of dry powder blending, powder characteristics, blender class types, working principles, the advantages and disadvantages of each mixer type, and factors that influence the outcome. We also discuss optimized powder sampling techniques for quality control personnel. The four to a six-hour lecture is followed immediately by a workshop or a hands-on equipment demonstration. The course contains a workshop with multiple problems to solve. Two hundred forty-seven references, 225 pages.

Basic Tablet Press Operation

This single-day or two-day course is designed as a hands-on program. The course provides a classroom lecture of 6 hours presenting the theory required to understand the fundamentals of running a tablet press and the specifics of many tablet types (Fette/Korsch/Kikusui/Cadmach etc.). The lecture is followed immediately by a hands-on equipment demonstration. Each participant will understand how a tablet press works, how to identify capping, picking and sticking, and other common tablet defects, and how they are reduced or eliminated with machine adjustments. For the two-day course, the operator must make changes during machine operation. Both book and course have a workshop with multiple problems to solve, and the two-day course has more time on the floor. Four hundred nine references, 566 pages.

Advanced Tablet Press Operation

The course is the only advanced course of its kind given today. Students are presumed to have some knowledge of tablet press operation. This one or two-day course covers advanced topics in great detail on proper press setup and tooling issues and has problem-solving on the production floor and analysis. There are also video examples of ideal press operation that highlights common problems with the tablet press. The course has a workshop and a problem-solving session. There are more problems to solve and more time on the floor with the two-day class. Two hundred thirty-eight references, 546 pages.

Advanced Tablet Press Operation (NON-Pharma)

The course is the only advanced course of its kind given today specifically for NON-Pharmaceutical applications. Students are presumed to have some knowledge of tablet press operation. This one or two-day course covers advanced topics in great detail on proper press setup and tooling issues and has problem-solving on the production floor and analysis of tablet defects. There are also video examples of ideal press operation that highlights common problems with the tablet press. The course has a workshop and a problem-solving session: 238 references, 35+ NON-pharma, and 494 pages.

Understanding and Preventing Overweight Tablets

This one or two-day course is the only course of its kind currently offered in the world and is an expanded version of the course given to the US FDA at Silver Spring, MD, in 2011. The course comprises an initial six-hour discussion of the fundamentals of tablet press setup and operation and a thorough discussion of the common defects on the production floor. This is followed by a shop floor session that reinforces the basic theory of a tablet press's correct setup and operation. The last topic is a review of the 18 known factors in a single-day course. Optional Day two is an intense review of the 18 known factors that cause overweight and underweight tablets. This six-hour discussion is followed by a shop floor session utilizing the firm's available presses to attempt to produce overweight and underweight tablets resulting from one or more factors. There is an additional discussion on the advantages and disadvantages of dimensional sorting. Finally, a formal computer challenge is presented that approaches perfection in assuring that overweight/underweight tablets are not present in the batch produced.   Six hundred fifty-two pages, 400+ references.

Introduction to Directly Compressible (DC) Tablet Manufacturing: Dry Powder Blending and Optimized Tablet Compressing

This is the only course of its kind available today. This single-day course is designed for departments wishing to understand better the science behind optimized DC powder preparation and tablet manufacturing. The course consists of two 4-hour classroom sessions and discusses common DC-based tablet defects and problem-solving. There is no hands-on session/no workshop. 451 pages, 263 references

Successful Compressing of Bead/Powder "MUPS" Formulations

This single-day introductory course provides the specific knowledge needed to successfully compress various Multiple Unit Particle System formulas (MUPS). We will review specific examples of current formulas and their associated problems. Based on current theory and good science, the course emphasizes the critical operating parameters that must be present for successful MUPS tablet compression. The course is 3-4 hours of theory, including requirements for reproducible content uniformity and dissolution results. This is followed by a shop floor demonstration on a tablet press, demonstrating the critical operating parameters for compressing MUPS tablets. 265 pages, 236 references

We also offer an optional additional second-day color coating module that discusses the technical issues associated with a successful color coating of MUPS tablets. This module is 1.5 hrs in the class, followed by a shop floor demonstration of successful MUPS film coating. Four hundred seventeen pages, 471 references.

Successful Manufacturing of OROS Formulations (NEW FOR 2020)

This single-day introductory course provides the specific knowledge needed to compress various OROS (Oral Osmotic) formulas successfully. We will review specific examples of current formulas and their associated problems. Based on current theory and good science, the course emphasizes the critical operating parameters that must be present for successful OROS tablet compression/coating/drilling. The course is 3-4 hours of theory, including requirements for reproducible content uniformity and dissolution results. This is followed by a shop floor demonstration on any available equipment, demonstrating the critical operating parameters for compressing OROS tablets. Two hundred sixty-five pages, 36 references.

Tablet Press Tooling: Design Optimization, Care, Preparation, and Storage

The course applies current science in designing and using optimized punches for success in the press. We discuss the physical attributes of the punch, head flat, use of reliefs, tapered dies, types of steel to use, and the various coatings available. We provide a checklist of tooling preparation items required for both polishing and buffing. We provide recommended materials for the total preparation and installation of optimized tooling for the tablet press.

Tablet Press Maintenance For Operators: The Correct Way to Maintain Any Tablet Press

This is the only course of its kind available today. This two-day+ course is designed for senior tablet press operators, maintenance mechanics, mechanical engineers, calibration technicians, and people wishing to better understand the science behind optimized press maintenance. There is an initial 6-hour classroom session followed by multiple sessions on the production floor demonstrating and reinforcing concepts learned in the classroom. The number of production floor sessions depends on the number of different press types (Fette/Korsch/Manesty, etc., presses).

Introduction to Aqueous Film Coating

This single-day/two-day course is engineered to provide a basic knowledge of a pharmaceutical or nutritional supplement coating operation. The course comprises a six-hour classroom lecture covering the basic knowledge needed to understand the fundamentals of film coating, equipment, application, and troubleshooting. A four-hour hands-on demonstration immediately follows this in the coating room. Both book and course have a workshop with multiple problems to solve. The two-day course has more time on the floor. One hundred eighty-seven references, 348 pages.

Introduction to Sugar Coating

This single-day/two-day course is engineered to provide a basic knowledge of classic sugar coating using either perforated or non-perforated coating pans. The course comprises a two-three hour classroom lecture covering the basic knowledge needed to understand the fundamentals of sugar coating, equipment, application, and troubleshooting. A four-hour hands-on demonstration immediately follows this in the coating room. Both book and course have a workshop with multiple problems to solve. Eleven references, 148 pages.

Introduction to Successful Functional Coating

This single-day/two-day course is engineered to provide a basic knowledge of a pharmaceutical enteric or extended-release function coating operation. The course comprises a six-hour classroom lecture covering the basic knowledge needed to understand the fundamentals of functional coating, equipment, application, and troubleshooting. A four-hour hands-on demonstration immediately follows this in the coating room. Both book and course have a workshop with multiple problems to solve, and the two-day course has more time on the floor. One hundred eighty-seven references, 348 pages.

Advanced Aqueous Film Coating

The course is the only advanced course of its kind given today. Students are presumed to have some knowledge of basic film coating. This two-day course covers advanced topics such as the effect of gun setup, pan pressure, inlet/outlet air temperature, spray rate, atomizing and pattern air, and particle adhesion on pan surfaces and their direct impact on tablet defects. The course includes video examples of proper pan operation and highlights common problems in the pan. The course has a workshop and a problem-solving session. One hundred forty-three references, 444 pages.

Understanding and Preventing Black Spots/Smudges on Coated Tablets

This half-day course is engineered to give students a complete understanding of how black and grey spots are produced. We present over 60 film coating formulas and discuss and link the probability of producing these common defects. Finally, we present a defense that may be used at any site and with any series of campaigns, regardless of the colors used. As an option, a full day course would have the lecture, followed by a hands-on demonstration in the coating room that is comprised of 1) a coating run producing black specs, 2) passivation of the pan, and 3) a second coating run demonstrating that the black specs and grey smudges have been eliminated. Both book and course have a workshop with multiple problems to solve. Twenty-one references, 135 pages.

Introduction to Tablet Printing

This is a half-day presentation for operators and line staff on the offset printing technology used in Pharmaceuticals and nutritional supplements. The course is considered the best tablet printing course in the world. The three-hour classroom lecture is followed immediately by a two to four-hour hands-on demonstration in the printing suite. Both book and course have a workshop with multiple problems to solve. There are four references and 141 pages.

Hard Shell Capsule Manufacturing: Choose a) Dosator/Breather Technology, or b) Dosing disc Technology or a combined course.

This single-day course is engineered to provide a basic knowledge of the theory and principles of pharmaceutical and nutritional supplement encapsulation, equipment selection, operation, and the advantages and disadvantages of each technology. The course is a four-hour presentation immediately followed by a hands-on demonstration in the encapsulation suite. All students are required to make both machine adjustments and perform in-process tests. The book and course contain a workshop with multiple problems to solve. (a) 77 references, (b) 61 references, 235 pages.

Introduction To Soft Gelatin Capsule Manufacturing

Completely revised for 2017! A single-day presentation for operators and line staff on the principles of soft gelatin technology. The course also covers critical operating parameters, common defects, and their root causes. The four to five-hour lecture is followed immediately by a four-hour hands-on demonstration in the soft gelatin manufacturing area. The book does not contain a workshop. Seventy-two references, 285 pages.

WÜrster Column Technology

The course is a single-day presentation for operators and line staff on the WÜrster seed and particle coating technology. The four-hour classroom lecture covers the principles of operation as well as machine set points and critical processing parameters. The lecture is followed immediately by a two to four-hour hands-on demonstration in the WÜrster suite. Both book and course contain a workshop with multiple problems to solve. One hundred twenty-three references, 200 pages.

III. Formulating Courses

Formulating and Manufacturing Nutritional Supplements

We assume you know what you want in a formula, or your customer told you what he wanted, but what comes next? Will it work, be cost-effective, or give more rework than it's worth? This is a two-day course that presents 11 different topics in basic formulating for both tablets and hard shell capsules. The topics covered are the introduction, understanding of raw materials, dose sizing and potency calculations, basic tablet press operation; common problems and resolution, basic encapsulation; of common problems and resolution, single entity vitamins, multiple entity vitamins, herbal formulas, sustained-release vitamin formulas, and a formulation of the workshop on. The textbook covers all subjects and includes a workshop and an optional final examination for certification as a formulator: fifty-three references, 601 pages plus 25 formulation problems to solve.

Formulating Effervescent Tablets

The course is a single-day presentation for formulators and those interested in learning how to formulate and manufacture effervescent tablets. The course covers the principles of formulation, common excipients used, and their application in effervescent tablet formulation. The book contains many examples of successful effervescent tablet formulas. Twenty-four references, 220 pages.

Formulating Oral Disintegrating Tablets (ODT) /Sublingual Tablets

A single-day presentation for formulators and those interested in learning how to formulate and manufacture sublingual tablets. The course covers the principles of formulation, common excipients used, and their application in sublingual tablet formulation. The book contains many examples of successful sublingual tablet formulas. One hundred eighty-five pages, 68 references.

Formulating Sustained Release Nutritional Supplements

A single-day presentation for formulators and those interested in learning how to formulate and manufacture sustained-release nutritional supplements. The book explains the various technical approaches to formulating a successfully sustained release tablet. The course covers the principles of formulation, common excipients used, and their application in sustained-release tablet formulation. The book contains many examples of successful sustained-release tablet formulas. 170 pages.

Individual Subject Modules For The University

  • Blending problems and over-blending of the lubricant
  • Successful tablet Compression of herbal products
  • MUPS technology and manufacturing challenges
  • Is pre-compression mostly misunderstood
  • Anodized Aluminum and its effect (tablet presses)
  • Automatic weight control, theory, and discussion
  • Bisects and tablet splitting, regulatory implications
  • Capping and lamination
  • Scale-up in aqueous film coating
  • The tablet compressing cycle, theory, and explanation
  • The glass transition phase and its effect on tableting
  • Coating low hardness tablets
  • Hygroscopicity and its effect on successful tablet production
  • If the overload trips, what should I do?
  • Lamination (cracks) and stability failures
  • Orally disintegrating tablets
  • The difference between pharmaceutical dyes and Lakes etc
  • Slugging versus roller compaction
  • Static electricity in blending and tablet compressing
  • The paradox of high shear granulating
  • The effect of correct blend occupancy on content uniformity and tablet hardness
  • Selecting the correct steel for punches and dies
  • Understanding Compressing Pressure:
  • The maximum tip pressure and its' relationship to tablet quality

Guest lectures for Universities and Government Agencies

  • MUPS technology and manufacturing challenges
  • Is Pre-compression mostly misunderstood
  • Hygroscopicity and Its' Effect on Tablet Manufacturing

Guest lectures at the US FDA, Silver Spring, Md.

F.A. Rowley: "Overweight Tablets Are Not Going Away Anytime Soon," presented to the US FDA, CDER Silver Spring, MD, May 2011

F.A. Rowley: "When Should We Stop The Tablet Press At Powder Run Out?", presented to the US FDA, CDER Silver Spring, MD, October 2014.

*NOTE: Some courses are unavailable in countries where a prior agreement exists between Solid Dosage Manufacturing, Inc. and The Center For Professional Advancement.